Chemical Structure : SGC-CLK-1
CAS No.:
748142-15-6
SGC-CLK-1
(CAF-170, CAF170)
Catalog No.: PC-21431Not For Human Use, Lab Use Only.
SGC-CLK-1 (CAF-170) is a potent and selective inhibitor of Cdc2-Like kinases CLK1, 2 and 4 with binding IC50 values of 13 nM, 4 nM, and 46 nM, resepctively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SGC-CLK-1 (CAF-170) is a potent and selective inhibitor of Cdc2-Like kinases CLK1, 2 and 4 with binding IC50 values of 13 nM, 4 nM, and 46 nM, resepctively.
SGC-CLK-1 (CAF-170) poorly inhibits CLK3 with IC50 of 363 nM.
SGC-CLK-1 (CAF-170) binds to CLK1, CLK2, and CLK4 with cellular IC50 values below 200 nM, with the CLK2 cellular affinity the best, at 58 nM.
SGC-CLK-1 (CAF-170) is active against multiple cancer types, not only reduces serine arginine rich (SR) protein phosphorylation, but also alters SR protein and CLK2 subcellular localization in a reversible way.
Physicochemical Properties
|
M.Wt
|
416.36
|
|
Formula
|
C19H15F3N6O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(3-methoxy-5-(trifluoromethyl)phenyl)-4-(6-methoxypyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine
|
References
1. Tiek D, et al. Curr Res Chem Biol. 2023;3:100045.
Contact Us
sales@probechem.com
