Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SGC-SMARCA-BRDVIII
CAS No.: 1997319-84-2
Catalog No.: PC-73226Not For Human Use, Lab Use Only.
SGC-SMARCA-BRDVIII (SMARCA-PB1 inhibitor 22) is a potent, selective pan-SMARCA/PB1 bromodomain inhibitor with Kd of 35, 36 and 13 nM for SMARCA2 (BRM), SMARCA4 (BRG1) and PB1 (5), respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SGC-SMARCA-BRDVIII (SMARCA-PB1 inhibitor 22) is a potent, selective pan-SMARCA/PB1 bromodomain inhibitor with Kd of 35, 36 and 13 nM for SMARCA2 (BRM), SMARCA4 (BRG1) and PB1 (5), respectively.
SGC-SMARCA-BRDVIII displays little to no affinity for PB1(2) PB1(3) and PB1(4) (IC50=1.9->10 uM).
SGC-SMARCA-BRDVIII blocked adipocyte differentiation at 1.0 μM in 3T3-L1 murine fibroblasts.
SGC-SMARCA-BRDVIII blocks the expression of key genes during adipogenesis, including the transcription factors PPARγ and C/EBPα, and impaired the differentiation of 3T3-L1 murine fibroblasts into adipocytes.
| M.Wt | 371.441 | |
| Formula | C19H25N5O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
tert-Butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]- piperazine-1-carboxylate |
|
1. Marek Wanior, et al. J Med Chem. 2020 Dec 10;63(23):14680-14699.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
