Catalog No.: PC-73226Not For Human Use, Lab Use Only.
SGC-SMARCA-BRDVIII (SMARCA-PB1 inhibitor 22) is a potent, selective pan-SMARCA/PB1 bromodomain inhibitor with Kd of 35, 36 and 13 nM for SMARCA2 (BRM), SMARCA4 (BRG1) and PB1 (5), respectively.
SGC-SMARCA-BRDVIII (SMARCA-PB1 inhibitor 22) is a potent, selective pan-SMARCA/PB1 bromodomain inhibitor with Kd of 35, 36 and 13 nM for SMARCA2 (BRM), SMARCA4 (BRG1) and PB1 (5), respectively.
SGC-SMARCA-BRDVIII displays little to no affinity for PB1(2) PB1(3) and PB1(4) (IC50=1.9->10 uM).
SGC-SMARCA-BRDVIII blocked adipocyte differentiation at 1.0 μM in 3T3-L1 murine fibroblasts.
SGC-SMARCA-BRDVIII blocks the expression of key genes during adipogenesis, including the transcription factors PPARγ and C/EBPα, and impaired the differentiation of 3T3-L1 murine fibroblasts into adipocytes.
