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Chemical Structure : SGC-iMLLT
CAS No.: 2255338-25-9
Catalog No.: PC-35710Not For Human Use, Lab Use Only.
SGC-iMLLT is the first small molecule chemical probe for the YEATS domain (YD) of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively, IC50 of 0.26 uM (MLLT1).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SGC-iMLLT is the first small molecule chemical probe for the YEATS domain (YD) of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively, IC50 of 0.26 uM (MLLT1).
SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interaction.
SGC-iMLLT dsiplays excellent selectivity over other human YD proteins (YEATS2/4) and bromodomains.
| M.Wt | 388.475 | |
| Formula | C22H24N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-1-methyl-N-(2-((2-methylpyrrolidin-1-yl)methyl)-1H-benzo[d]imidazol-5-yl)-1H-indazole-5-carboxamide |
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1. Moustakim M, et al. Angew Chem Int Ed Engl. 2018 Oct 5. doi: 10.1002/anie.201810617.
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