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SGI-1027

Chemical Structure : SGI-1027

CAS No.: 1020149-73-8

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SGI-1027 (SGI1027;SGI 1027)

Catalog No.: PC-43810Not For Human Use, Lab Use Only.

SGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B.
SGI-1027 induces selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B in different cancer cell lines.

Physicochemical Properties

M.Wt 461.5178
Formula C27H23N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 27 mg/mL
Chemical Name/SMILES

Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-

References

1. Datta J, et al. Cancer Res. 2009 May 15;69(10):4277-85.

2. Rilova E, et al. ChemMedChem. 2014 Mar;9(3):590-601.

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