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Chemical Structure : SHP-1 agonist SC-43
CAS No.: 1400989-25-4
Catalog No.: PC-20911Not For Human Use, Lab Use Only.
SHP-1 agonist SC-43 is a potent and orally active SHP-1 (PTPN6) agonist, SC-43 interacts with the N-SH2 domain of SHP-1 to enhance the activity of SHP-1.
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SHP-1 agonist SC-43 is a potent and orally active SHP-1 (PTPN6) agonist, SC-43 interacts with the N-SH2 domain of SHP-1 to enhance the activity of SHP-1.
SHP-1 agonist SC-43 is a sorafenib derivative but displays more potent anti-HCC activity than sorafenib.
SHP-1 agonist SC-43 treatment reduced the activated HSCs and thus effectively prevented and regressed liver fibrosis in both fibrosis mouse models and improved mouse survival.
SC-43 promoted HSC apoptosis, increased the SHP-1 activity and inhibited phospho-STAT3.
| M.Wt | 431.80 | |
| Formula | C21H13ClF3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(4-cyanophenoxy)phenyl)urea |
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1. Tai WT, et al. Hepatology. 2014 Jan;59(1):190-201.
2. Su TH, et al. Sci Rep. 2017 May 11;7(1):1728.
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