Catalog No.: PC-20911Not For Human Use, Lab Use Only.
SHP-1 agonist SC-43 is a potent and orally active SHP-1 (PTPN6) agonist, SC-43 interacts with the N-SH2 domain of SHP-1 to enhance the activity of SHP-1.
SHP-1 agonist SC-43 is a potent and orally active SHP-1 (PTPN6) agonist, SC-43 interacts with the N-SH2 domain of SHP-1 to enhance the activity of SHP-1. SHP-1 agonist SC-43 is a sorafenib derivative but displays more potent anti-HCC activity than sorafenib. SHP-1 agonist SC-43 treatment reduced the activated HSCs and thus effectively prevented and regressed liver fibrosis in both fibrosis mouse models and improved mouse survival. SC-43 promoted HSC apoptosis, increased the SHP-1 activity and inhibited phospho-STAT3.
