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SHP1705

Chemical Structure : SHP1705

CAS No.: 1817737-04-4

SHP1705 (Cryptochrome modulator 50)

Catalog No.: PC-22367Not For Human Use, Lab Use Only.

SHP1705 is a small molecule cryptochrome (CRY) modulator and stabilizer, represses the expression of DBP, CRY1, and PER1, reduces glucose intolerance in obese, insulin-resistant mice.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SHP1705 is a small molecule cryptochrome (CRY) modulator and stabilizer, represses the expression of DBP, CRY1, and PER1, reduces glucose intolerance in obese, insulin-resistant mice.

Physicochemical Properties

M.Wt 345.35
Formula C18H17F2N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(3-(3,6-difluoro-9H-carbazol-9-yl)-2-hydroxypropyl)imidazolidin-2-one

References

1. Paul S Humphries, et al. Bioorg Med Chem Lett. 2018 Feb 1;28(3):293-297.

2. Yuanzhong Pan, et al. bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.590360.

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