SHP2-IN-2 |CAS:2162951-06-4 Probechem Biochemicals

Chemical Structure : SHP2-IN-2

SHP2-IN-2

Catalog No.: PC-63257Not For Human Use, Lab Use Only.

SHP2-IN-2 is a selective, allosteric inhibitor of protein tyrosine phosphatase SHP2, preferentially inhibits SHP2 F285S over the PTP domain and allosteric site mutant.

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Biological Activity

SHP2-IN-2 is a selective, allosteric inhibitor of protein tyrosine phosphatase SHP2, preferentially inhibits SHP2 F285S over the PTP domain and allosteric site mutant。
SHP2-IN-2 reduces the viability of MOLM14 cells with IC50 of 85 uM.

Physicochemical Properties

M.Wt	342.797
Formula	C17H11ClN2O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-benzyl-8-chloro-2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one

References

1. LaRochelle JR, et al. Bioorg Med Chem. 2017 Dec 15;25(24):6479-6485.

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SHP2-IN-2

Biological Activity

Physicochemical Properties

References

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