SHP2 inhibitor 17g

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Chemical Structure : SHP2 inhibitor 17g

Catalog No.: PC-27065Not For Human Use, Lab Use Only.

SHP2 inhibitor 17g is a potent and selective allosteric SHP2 inhibitor with IC50 of 49 nM (SHP2 WT).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SHP2 inhibitor 17g is a potent and selective allosteric SHP2 inhibitor with IC50 of 49 nM (SHP2 WT).
SHP2 inhibitor 17g also effectively suppresses ERK phosphorylation in MV-4-11, Panc-1, and KYSE520 cells with an IC50 of 50, 250, and 410 nM, respectively.
SHP2 inhibitor 17g shows limited activity against the isolated catalytic PTP domain of SHP2.
SHP2 inhibitor 17g exhibits growth inhibition with IC50 of 70 nM for MV-4-11 cells.

Physicochemical Properties

M.Wt	480.40
Formula	C24H23Cl2N7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1'-(3-amino-2-(2,3-dichlorophenyl)-2H-pyrazolo[3,4-b]pyrazin-6-yl)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine

References

1. Amoussa M, et al. ChemMedChem. 2026 Jun 15;21(11):e70341.

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