Catalog No.: PC-70314Not For Human Use, Lab Use Only.
A potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2.
SI-2 (EPH116) hydrochloride is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2.
SI-2 (EPH116) selectively reduces cellular protein levels of SRC-3, but not that of CARM-1.
SI-2 (EPH116) blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells; significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model.
SI-2 (EPH116) is a "first-in-class" compound that targets oncogenic coactivator.
