Chemical Structure : SI409-1
CAS No.:
SI409-1
Catalog No.: PC-27990Not For Human Use, Lab Use Only.
SI409-1 is a specific small molecule inhibitor of dihydrolipoamide S-succinyltransferase (DLST) lysine 409 (K409), effectively inhibits DLST K409 succinylation (K409succ).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SI409-1 is a specific small molecule inhibitor of dihydrolipoamide S-succinyltransferase (DLST) lysine 409 (K409), effectively inhibits DLST K409 succinylation (K409succ).
Dihydrolipoamide S-succinyltransferase (DLST) is the E2 subunit of the α-ketoglutarate dehydrogenase complex (KGDHC) in the TCA cycle.
SI409-1 significantly inhibits DLST K409succ in lung adenocarcinoma (LUAD) cells without altering the global cellular succinylation level.
SI409-1 can inhibit the malignant progression of LUAD cells by suppressing DLST K409succ.
SI409-1 enhances the sensitivity of LUAD to cuproptosis and significantly inhibits the malignant progression of LUAD.
Physicochemical Properties
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M.Wt
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387.29
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Formula
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C20H30BN3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(4-((3S,4R)-3-(4-acetyl-1,4-diazepan-1-yl)-4-methylpyrrolidine-1-carbonyl)-2-methylphenyl)boronic acid
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References
1. Xuanxuan Li, et al. Adv Sci (Weinh). 2026 Aug 30:e77528.
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