SID 26681509 is a potent, selective inhibitor of lysosome hydrolase cathepsin L with IC50 of 56 nM, displays no inhibitory activity at cathepsin G.
SID 26681509 displays 7- to 151-fold greater selectivity toward cathepsin L than papain and cathepsins B, K, V, and S.
SID 26681509 demonstrated a lack of toxicity in human aortic endothelial cells and zebrafish.
SID 26681509 inhibited in vitro propagation of malaria parasite Plasmodium falciparum with IC50 of 15.4 microM and inhibited Leishmania major with IC50 of 12.5 microM.
