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Chemical Structure : SID 26681509
CAS No.: 958772-66-2
Catalog No.: PC-38582Not For Human Use, Lab Use Only.
SID 26681509 is a potent, selective inhibitor of lysosome hydrolase cathepsin L with IC50 of 56 nM, displays no inhibitory activity at cathepsin G.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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SID 26681509 is a potent, selective inhibitor of lysosome hydrolase cathepsin L with IC50 of 56 nM, displays no inhibitory activity at cathepsin G.
SID 26681509 displays 7- to 151-fold greater selectivity toward cathepsin L than papain and cathepsins B, K, V, and S.
SID 26681509 demonstrated a lack of toxicity in human aortic endothelial cells and zebrafish.
SID 26681509 inhibited in vitro propagation of malaria parasite Plasmodium falciparum with IC50 of 15.4 microM and inhibited Leishmania major with IC50 of 12.5 microM.
| M.Wt | 539.651 | |
| Formula | C27H33N5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan 2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide |
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1. Shah PP, et al. Mol Pharmacol. 2008 Jul;74(1):34-41.
2. Campbell GR, et al. PLoS Pathog. 2012;8(5):e1002689.
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