SIRT2 inhibitor 24a

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Chemical Structure : SIRT2 inhibitor 24a

Catalog No.: PC-25497Not For Human Use, Lab Use Only.

SIRT2 inhibitor 24a is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.85 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SIRT2 inhibitor 24a is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.85 uM.
SIRT2 inhibitor 24a dose-dependently elevates the acetylation level of α-tubulin in the non-small cell lung cancer H441 cells.
SIRT2 inhibitor 24a restrains cell growth mainly through inhibiting cellular proliferation rather than inducing apoptosis.
SIRT2 inhibitor 24a could suppress the migration and invasion of H441 cells.

Physicochemical Properties

M.Wt	502.59
Formula	C26H26N6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazole-4-carboxamide, N-[4-[[3-[[2-[(4,6-dimethyl-2-pyrimidinyl)thio]acetyl]amino]phenyl]methoxy]phenyl]-1-methyl-

References

1. Yang LL, et, al. Eur J Med Chem. 2018 Jul 15;155:806-823.

2. Wirawan R, et al. RSC Med Chem. 2025 Aug 19. doi: 10.1039/d5md00144g.

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