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Chemical Structure : SIRT2 inhibitor 33a
Catalog No.: PC-21146Not For Human Use, Lab Use Only.
SIRT2 inhibitor 33a is a potent, specific Sirtuin 2 (SIRT2) inhibitor with IC50 of 1.0 uM, no activity against SIRT1 and SIRT3 (IC50>100 uM).
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SIRT2 inhibitor 33a is a potent, specific Sirtuin 2 (SIRT2) inhibitor with IC50 of 1.0 uM, no activity against SIRT1 and SIRT3 (IC50>100 uM).
SIRT2 inhibitor 33a induces a dose-dependent selective increase of α-tubulin acetylation in human colon cancer HCT116 cells.
| M.Wt | 332.40 | |
| Formula | C21H20N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Takayoshi Suzuki, et al. J Med Chem. 2012 Jun 28;55(12):5760-73.
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