SIRT2 inhibitor 33a

Chemical Structure : SIRT2 inhibitor 33a

Catalog No.: PC-21146Not For Human Use, Lab Use Only.

SIRT2 inhibitor 33a is a potent, specific Sirtuin 2 (SIRT2) inhibitor with IC50 of 1.0 uM, no activity against SIRT1 and SIRT3 (IC50>100 uM).

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Biological Activity

SIRT2 inhibitor 33a is a potent, specific Sirtuin 2 (SIRT2) inhibitor with IC50 of 1.0 uM, no activity against SIRT1 and SIRT3 (IC50>100 uM).
SIRT2 inhibitor 33a induces a dose-dependent selective increase of α-tubulin acetylation in human colon cancer HCT116 cells.

Physicochemical Properties

M.Wt	332.40
Formula	C21H20N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N)C1=CC=CC=C1NC2=CC=CC(OCCC3=CC=CC=C3)=C2

References

1. Takayoshi Suzuki, et al. J Med Chem. 2012 Jun 28;55(12):5760-73.

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