SIRT2 inhibitor 55

Chemical Structure : SIRT2 inhibitor 55

Catalog No.: PC-72773Not For Human Use, Lab Use Only.

SIRT2 inhibitor 55 is a potent and selective SIRT2 inhibitor with IC50 of 250 nM.

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Biological Activity

SIRT2 inhibitor 55 is a potent and selective SIRT2 inhibitor with IC50 of 250 nM.
SIRT2 inhibitor 55 displays >300 to >800-fold selectivity over SIRT1 and 3, respectively.
SIRT2 inhibitor 55 dose-dependently increases tubulin acetylation in treated non-small cell lung cancer cell line NCI-H460.
SIRT2 inhibitor 55 shows cytotoxicity in in B-cell lymphoma and other cancer cell lines (Raji cell IC50=11.9 uM).

Physicochemical Properties

M.Wt	551.36
Formula	C25H22BrF3N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Solubility
Chemical Name/SMILES

References

1. Chowdhury S, et al. Molecules. 2020 Jan 21;25(3):455.

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