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Chemical Structure : SIRT2 inhibitor 56
Catalog No.: PC-72774Not For Human Use, Lab Use Only.
SIRT2 inhibitor 56 is a potent selective SIRT2 inhibitor with IC50 of 780 nM.
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SIRT2 inhibitor 56 is a potent selective SIRT2 inhibitor with IC50 of 780 nM.
SIRT2 inhibitor 56 displays >300 to >800-fold selectivity over SIRT1 and 3, respectively.
SIRT2 inhibitor 56 dose-dependently increases tubulin acetylation in treated non-small cell lung cancer cell line NCI-H460.
SIRT2 inhibitor 56 shows cytotoxicity in in B-cell lymphoma and other cancer cell lines (Raji cell IC50=9.1 uM).
SIRT2 inhibitor 56 induces apoptosis and shows anti-proliferation effect in OCI-Ly8-LAM53 (OCI) cells.
| M.Wt | 491.179 | |
| Formula | C21H17Br2NO3 | |
| Appearance | Solid | |
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1. Chowdhury S, et al. Molecules. 2020 Jan 21;25(3):455.
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