SIRT2 inhibitor 56

Chemical Structure : SIRT2 inhibitor 56

Catalog No.: PC-72774Not For Human Use, Lab Use Only.

SIRT2 inhibitor 56 is a potent selective SIRT2 inhibitor with IC50 of 780 nM.

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Biological Activity

SIRT2 inhibitor 56 is a potent selective SIRT2 inhibitor with IC50 of 780 nM.
SIRT2 inhibitor 56 displays >300 to >800-fold selectivity over SIRT1 and 3, respectively.
SIRT2 inhibitor 56 dose-dependently increases tubulin acetylation in treated non-small cell lung cancer cell line NCI-H460.
SIRT2 inhibitor 56 shows cytotoxicity in in B-cell lymphoma and other cancer cell lines (Raji cell IC50=9.1 uM).
SIRT2 inhibitor 56 induces apoptosis and shows anti-proliferation effect in OCI-Ly8-LAM53 (OCI) cells.

Physicochemical Properties

M.Wt	491.179
Formula	C21H17Br2NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Chemical Name/SMILES

References

1. Chowdhury S, et al. Molecules. 2020 Jan 21;25(3):455.

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