SIRT2 inhibitor AF8

Chemical Structure : SIRT2 inhibitor AF8

Catalog No.: PC-25498Not For Human Use, Lab Use Only.

SIRT2 inhibitor AF8 is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.06 uM.

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Biological Activity

SIRT2 inhibitor AF8 is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.06 uM.
AF8 demonstrated broad cytotoxicity amongst cancer cell lines, but minimal toxicity in noncancerous cells.
AF8 inhibited the anchorage-independent growth of human colorectal cancer cell line HCT116 with GI50 values of ~7 μM.
AF8 potently inhibited tumor growth in a HCT116 xenograft murine model.

Physicochemical Properties

M.Wt	526.74
Formula	C29H42N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	benzyl (S)-(6-(3-octylthioureido)-1-oxo-1-(phenylamino)hexan-2-yl)carbamate

References

1. Ali Sohail Farooqi, et al. J Med Chem. 2019 Apr 25;62(8):4131-4141.

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