SIRT2 inhibitor KPM-2

Chemical Structure : SIRT2 inhibitor KPM-2

Catalog No.: PC-25499Not For Human Use, Lab Use Only.

KPM-2 is a potent, selective, substrate-competitive sirtuin-2 (SIRT2) inhibitor with IC50 of 55 nM, >25-fold selective over SIRT1 and SIRT3.

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Biological Activity

KPM-2 is a potent, selective, substrate-competitive sirtuin-2 (SIRT2) inhibitor with IC50 of 55 nM, >25-fold selective over SIRT1 and SIRT3.
KPM-2 engages in a nucleophilic attack toward NAD+ at the active site of SIRT2.
KPM-2 exhibits antiproliferative activity in cancer cells and remarkable neurite outgrowth activity.

Physicochemical Properties

M.Wt	738.90
Formula	C40H46N6O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	benzyl ((S)-1-(((S)-1-amino-1-oxopropan-2-yl)amino)-1-oxo-6-(2-(2-((3-phenethoxyphenyl)amino)benzamido)ethanethioamido)hexan-2-yl)carbamate

References

1. Mellini P, et al. Chem Sci. 2017 Sep 1;8(9):6400-6408.

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