SIRT2 inhibitor RW-78 | SIRT2 inhibitor

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Chemical Structure : SIRT2 inhibitor RW-78

SIRT2 inhibitor RW-78 (SIRT2 inhibitor 29)

Catalog No.: PC-25496Not For Human Use, Lab Use Only.

SIRT2 inhibitor RW-78 is a potent, ubtype selective, NAD+ independent SIRT2 inhibitor with IC50 of 26 nM, has high selective against SIRT1, 3 and 5, shows cellular target engagement via NanoBRET assays in HEK293T cells with EC50 of 15 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	537.04
Formula	C26H25ClN6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-Chloro-4-((3-(2-((4,6-dimethylpyrimidin-2-yl)thio)acetamido)benzyl)oxy)phenyl)-1-methyl-1H-pyrazole-4-carboxamide

References

1. Wirawan R, et al. RSC Med Chem. 2025 Aug 19. doi: 10.1039/d5md00144g.

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