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Chemical Structure : SIRT3 activator MY-13
Catalog No.: PC-22069Not For Human Use, Lab Use Only.
SIRT3 activator MY-13 is a small-molecule activator of SIRT3, inhibits CRC cell proliferation and migration.
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SIRT3 activator MY-13 is a small-molecule activator of SIRT3, inhibits CRC cell proliferation and migration.
MY-13 inhibits colorectal cancer cell growth in vitro with IC50 of 5.23 μM in RKO cells and 14.71 μM in HCT-116 cells.
MY-13 (40, 80 mg.kg) effectively inhibits the growth of colorectal cancer in vivo without apparent systemic toxicity.
MY-13 (10 uM) attenuates colorectal cancer cell migration in vitro, induces autophagy-dependent cell death in CRC.
MY-13 inhibits proliferation and migration via the SIRT3/Hsp90/AKT pathway in CRC.
| M.Wt | 317.33 | |
| Formula | C18H12FN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mou Y, et al. Bioorg Chem. 2024 Apr 2;146:107327.
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