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SIRT3 inhibitor 8

Chemical Structure : SIRT3 inhibitor 8

CAS No.:

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SIRT3 inhibitor 8

Catalog No.: PC-72772Not For Human Use, Lab Use Only.

SIRT3 inhibitor 8 is a SIRT3 selective inhibitor with IC50 of 6 uM, 6.8- and 5.3-fold selectivity for SIRT3 versus SIRT1 and SIRT2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SIRT3 inhibitor 8 is a SIRT3 selective inhibitor with IC50 of 6 uM, 6.8- and 5.3-fold selectivity for SIRT3 versus SIRT1 and SIRT2.
SIRT3 inhibitor 8 reduced DLBCL cell viability and triggered activation of autophagy.

Physicochemical Properties

M.Wt 436.511
Formula C28H24N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
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Solubility

Chemical Name/SMILES

References

1. Sumit S Mahajan, et al. J Med Chem. 2014 Apr 24;57(8):3283-94.

2. Meng Li, et al. Cancer Cell. 2019 Jun 10;35(6):916-931.e9.

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