SIRT5 inhibitor 32

Chemical Structure : SIRT5 inhibitor 32

Catalog No.: PC-72766Not For Human Use, Lab Use Only.

SIRT5 inhibitor 32 is an efficient, cellularly active small molecule that targets SIRT5.

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Biological Activity

SIRT5 inhibitor 32 is an efficient, cellularly active small molecule that targets SIRT5.
SIRT5 inhibitor 32 inhibits cell growth of SIRT5-dependent AML cell lines SKM-1, OCIAML2 and MOLM-13 with IC50 of 9, 20, and 24 uM, respectively.
SIRT5 inhibitor 32 is also shown to inhibit SIRT5 in HeLa cells by using an assay that produce in-cell fluoresence in response to SIRT5 activity in the mitochondria.
SIRT5 inhibitor 32 displays cytoselective toxicity towards SIRT5-dependent AML cells (SKM-1) over HEK293T cells in culture.

Physicochemical Properties

M.Wt	855.062
Formula	C40H55FN10O6S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Chemical Name/SMILES

References

1. Nima Rajabi, et al. Angew Chem Int Ed Engl. 2022 Mar 17.

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