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Chemical Structure : SIRT5 inhibitor 32
Catalog No.: PC-72766Not For Human Use, Lab Use Only.
SIRT5 inhibitor 32 is an efficient, cellularly active small molecule that targets SIRT5.
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SIRT5 inhibitor 32 is an efficient, cellularly active small molecule that targets SIRT5.
SIRT5 inhibitor 32 inhibits cell growth of SIRT5-dependent AML cell lines SKM-1, OCIAML2 and MOLM-13 with IC50 of 9, 20, and 24 uM, respectively.
SIRT5 inhibitor 32 is also shown to inhibit SIRT5 in HeLa cells by using an assay that produce in-cell fluoresence in response to SIRT5 activity in the mitochondria.
SIRT5 inhibitor 32 displays cytoselective toxicity towards SIRT5-dependent AML cells (SKM-1) over HEK293T cells in culture.
| M.Wt | 855.062 | |
| Formula | C40H55FN10O6S2 | |
| Appearance | Solid | |
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1. Nima Rajabi, et al. Angew Chem Int Ed Engl. 2022 Mar 17.
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