SIRT5 inhibitor 49 | SIRT5 inhibitor | Probechem Biochemicals

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Chemical Structure : SIRT5 inhibitor 49

SIRT5 inhibitor 49 (Sirt5-i)

Catalog No.: PC-72767Not For Human Use, Lab Use Only.

SIRT5 inhibitor 49 (Sirt5-i) is a potent and specific SIRT5 inhibitor with IC50 of 0.11 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SIRT5 inhibitor 49 (Sirt5-i) is a potent and specific SIRT5 inhibitor with IC50 of 0.11 uM.
SIRT5 inhibitor 49 also reduced SARS-CoV-2 viral levels in cell-culture experiments.
SIRT5 catalytic domain is necessary for the interaction with Nsp14, but that Nsp14 does not appear to be directly deacylated by SIRT5.

Physicochemical Properties

M.Wt	674.807
Formula	C31H39FN6O6S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Chemical Name/SMILES

References

1. Nima Rajabi, et al. Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14836-14841.

2. Nima Rajabi, et al. Angew Chem Int Ed Engl. 2022 Mar 17.

3. Walter M, et al. bioRxiv. 2022 Jan 5:2022.01.04.474979.

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