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Chemical Structure : SIRT6 inhibitor S6
Catalog No.: PC-21890Not For Human Use, Lab Use Only.
SIRT6 inhibitor S6 (SIRT6-IN-1) is a selective SIRT6 inhibitor with IC50 of 106 nM, 114 nM and 314 nM for SIRT6, SIRT2 and SIRT1 respectively.
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SIRT6 inhibitor S6 (SIRT6-IN-1) is a selective SIRT6 inhibitor with IC50 of 106 uM, 114 uM and 314 uM for SIRT6, SIRT2 and SIRT1 respectively.
SIRT6 inhibitor S6 increases acetylation at SIRT6 target lysines on histone 3, reduces TNF-α secretion, GLUT-1 upregulation, and increases glucose uptake.
| M.Wt | 410.40 | |
| Formula | C19H14N4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Elena Abbotto, et al. Biomed Pharmacother. 2023 Oct:166:115326.
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