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SJ-172550

Chemical Structure : SJ-172550

CAS No.: 431979-47-4

SJ-172550 (SJ172550;SJ 172550)

Catalog No.: PC-45010Not For Human Use, Lab Use Only.

The first small molecule MDMX inhibitor that reversibly binds the p53-binding pocket of MDMX, disrupts MDMX-p53 interaction with EC50 of 2.3 uM..

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Biological Activity

The first small molecule MDMX inhibitor that reversibly binds the p53-binding pocket of MDMX, disrupts MDMX-p53 interaction with EC50 of 2.3 uM.

Physicochemical Properties

M.Wt 428.8655
Formula C22H21ClN2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Acetic acid, 2-[2-chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-, methyl ester

References

1. Reed D, et al. J Biol Chem. 2010 Apr 2;285(14):10786-96.

2. Bista M, et al. PLoS One. 2012;7(6):e37518.

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