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SJ572946

Chemical Structure : SJ572946

CAS No.: 78584-09-5

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SJ572946 (SJ 572946)

Catalog No.: PC-20313Not For Human Use, Lab Use Only.

SJ572946 is a small molecule BAK activator, binds to the activation groove of BAK and selectively triggers BAK activation over that of BAX in liposome and mitochondrial permeabilization assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SJ572946 is a small molecule BAK activator, binds to the activation groove of BAK and selectively triggers BAK activation over that of BAX in liposome and mitochondrial permeabilization assays.
    In combination with apoptotic inducers and BH3 mimetics, SJ572946 kills experimental cancer cell lines.
    SJ572946 also cooperates with the endogenous BAK activator BID in activating a misfolded BAK mutant substantially impaired in activation.

    Physicochemical Properties

    M.Wt 198.67
    Formula C8H7ClN2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-chloro-4-methylbenzo[d]thiazol-2-amine

    References

    1. Giridhar Sekar, et al. iScience. 2022 Sep 6;25(10):105064.

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