Catalog No.: PC-61904Not For Human Use, Lab Use Only.
SJ733 (SJ000557733, SJ-557733) is an anti-malarial compound that targets ATP4 (PfATP4), a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite.
SJ733 (SJ000557733, SJ-557733) is an anti-malarial compound that targets ATP4 (PfATP4), a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite.
SJ733 displays high potency in vitro against all tested strains of P. falciparum with EC50 of 10-60 nM.
SJ733 kills parasites and the high fitness cost associated with resistance-conferring mutations appear to slow and suppress the selection of highly drug-resistant mutants in vivo; high oral bioavailability.
