SJB2-043 is a small molecule, specific USP1 inhibitor, inhibits USP1/UAF1 complex with IC50 of 0.544 uM.
SJB2-043 is an inhibitor of the native USP1/UAF1 complex.
SJB2-043 promotes ID1 degradation and inhibits growth of the leukemic cell line K562, also causes a decrease in the levels of other ID proteins, namely ID2 and ID3.
SJB2-043 causes cytotoxicity in multiple AML cell line K562 with EC50 of 1.07 uM, and exhibits growth inhibition of primary AML cells from patients.
SJB2-043 increases the levels of Ub-FANCD2, decreases the HR activity, and sensitizes the cells to chemotherapy agents.
SJB2-043 also inhibits SARS-CoV-2 papain-like protease (PLpro) with IC50 of <10 uM.
Physicochemical Properties
M.Wt
275.26
Formula
C17H9NO3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-Phenylnaphtho[2,3-d]oxazole-4,9-dione
References
1. Mistry H, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62.
2. Chia-Chuan Cho, et al. ChemMedChem. 2022 Jan 5;17(1):e202100455.
