Catalog No.: PC-35989Not For Human Use, Lab Use Only.
SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation.
SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation.
SK609 reverses akinesia and reduces L-dopa-induced dyskinesia in a hemiparkinsonian rat model of Parkinson's desease.
Physicochemical Properties
M.Wt
220.137
Formula
C10H15Cl2N
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-(2-Chlorophenyl)butan-2-amine hydrochloride
References
1. Marshall CA, et al. Neuropharmacology. 2019 Jan 8. pii: S0028-3908(19)30002-4.
2. Xu W, et al. ACS Chem Neurosci. 2017 Mar 15;8(3):486-500.
3. Kuzhikandathil EV, et al. Pharm Res. 2012 Aug;29(8):2264-75.
