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Chemical Structure : SK609
Catalog No.: PC-35989Not For Human Use, Lab Use Only.
SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation.
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SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation; reverses akinesia and reduces L-dopa-induced dyskinesia in a hemiparkinsonian rat model of Parkinson's desease.
| M.Wt | 220.137 | |
| Formula | C10H15Cl2N | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marshall CA, et al. Neuropharmacology. 2019 Jan 8. pii: S0028-3908(19)30002-4.
2. Xu W, et al. ACS Chem Neurosci. 2017 Mar 15;8(3):486-500.
3. Kuzhikandathil EV, et al. Pharm Res. 2012 Aug;29(8):2264-75.
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