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Chemical Structure : SKF 83566 hydrobromide
CAS No.: 108179-91-5
Catalog No.: PC-60665Not For Human Use, Lab Use Only.
SKF 83566 hydrobromide is a potent, selective dopamine D1 receptor antagonist with Ki of 0.56 nM.
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|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $468 | In stock | |
| 100 mg | Get quote |
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SKF 83566 hydrobromide is a potent, selective dopamine D1 receptor antagonist with Ki of 0.56 nM.
SKF 83566 shows no significant activity for D2 receptors (KB=2 uM), also is a potent antagonist of the vascular 5-HT2 receptor with Ki of 11 nM.
SKF 83566 also inhibits the dopamine transporter with IC50 of 0.51 uM, attenuate cocaine effects in vivo.
| M.Wt | 413.15 | |
| Formula | C17H18BrNO.HBr | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide |
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1. O'Boyle KM, et al. Eur J Pharmacol. 1984 Oct 30;106(1):219-20.
2. Ohlstein EH, et al. Eur J Pharmacol. 1985 Jan 22;108(2):205-8.
3. Molloy AG, et al. Eur J Pharmacol. 1985 Oct 8;116(1-2):183-6.
4. Stouffer MA, et al. J Neurochem. 2011 Sep;118(5):714-20.
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