Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-GPCR-Dopamine Receptor-SKF 83566 hydrobromide
SKF 83566 hydrobromide

Chemical Structure : SKF 83566 hydrobromide

CAS No.: 108179-91-5

SKF 83566 hydrobromide (SKF-83566 hydrobromide;SKF83566 hydrobromide)

Catalog No.: PC-60665Not For Human Use, Lab Use Only.

SKF 83566 hydrobromide is a potent, selective dopamine D1 receptor antagonist with Ki of 0.56 nM.

Packing Price Stock Quantity
10 mg $188 In stock
25 mg $298 In stock
50 mg $468 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SKF 83566 hydrobromide is a potent, selective dopamine D1 receptor antagonist with Ki of 0.56 nM.
SKF 83566 shows no significant activity for D2 receptors (KB=2 uM), also is a potent antagonist of the vascular 5-HT2 receptor with Ki of 11 nM.
SKF 83566 also inhibits the dopamine transporter with IC50 of 0.51 uM, attenuate cocaine effects in vivo.

Physicochemical Properties

M.Wt 413.15
Formula C17H18BrNO.HBr
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide

References

1. O'Boyle KM, et al. Eur J Pharmacol. 1984 Oct 30;106(1):219-20.

2. Ohlstein EH, et al. Eur J Pharmacol. 1985 Jan 22;108(2):205-8.

3. Molloy AG, et al. Eur J Pharmacol. 1985 Oct 8;116(1-2):183-6.

4. Stouffer MA, et al. J Neurochem. 2011 Sep;118(5):714-20.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: