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SKL-1223

Chemical Structure : SKL-1223

CAS No.: 3093938-66-7

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SKL-1223 (SKL1223)

Catalog No.: PC-28102Not For Human Use, Lab Use Only.

SKL-1223 is an orally bioavailable small molecule inhibitor of thioredoxin-interacting protein (TXNIP) with IC50 of 0.64 uM, attenuates TXNIP transcription factor binding, promotes beta-cell formation and loss of alpha-cells, exhibits potent glucose-lowering effects in streptozotocin-induced and db/db murine models.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SKL-1223 is an orally bioavailable small molecule inhibitor of thioredoxin-interacting protein (TXNIP) with IC50 of 0.64 uM, attenuates TXNIP transcription factor binding, promotes beta-cell formation and loss of alpha-cells, exhibits potent glucose-lowering effects in streptozotocin-induced and db/db murine models.

Physicochemical Properties

M.Wt 317.35
Formula C19H15N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(furan-2-ylmethyl)-4-(3-phenyl-1,2,4-oxadiazol-5-yl)aniline

References

1. Luo Z, et al. J Med Chem. 2026 Sep 10;69(17):20839-20858.

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