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Chemical Structure : SKL2001
CAS No.: 909089-13-0
Catalog No.: PC-35350Not For Human Use, Lab Use Only.
SKL2001 is a specific small molecule activator (agonist) of the Wnt/β-catenin pathway, stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $428 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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SKL2001 is a specific small molecule activator (agonist) of the Wnt/β-catenin pathway, stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.
SKL2001 strongly activates β-catenin responsive transcription, upregulates TOPflash reporter activity without effect on the activity of FOPFlash with mutated β-catenin/Tcf-binding elements, as well as either NF-κB or p53 reporter activity.
SKL2001 upregulates the expression of Axin2, inhibits N-terminal β-catenin phosphorylation without affecting GSK-3β activity.
SKL2001 suppresses preadipocyte differentiation, the alternative mesenchymal differentiation pathway.
| M.Wt | 286.291 | |
| Formula | C14H14N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-Furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl)-amide |
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1. Gwak J, et al. Cell Res. 2012 Jan;22(1):237-47.
2. DiRenzo DM, et al. Cell Signal. 2016 May;28(5):498-505.
3. Ohashi W, et al. Biochem Biophys Res Commun. 2017 Nov 25;493(3):1342-1348.
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