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Chemical Structure : SKLB-C05
Catalog No.: PC-35916Not For Human Use, Lab Use Only.
SKLB-C05 is a novel selective, orally active TOPK inhibitor with IC50 of 0.5 nM, shows excellent cytotoxicity and anti-migration and invasion activity on TOPK high-expressing CRC cells and induces cell apoptosis.
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SKLB-C05 is a novel selective, orally active TOPK inhibitor with IC50 of 0.5 nM, shows excellent cytotoxicity and anti-migration and invasion activity on TOPK high-expressing CRC cells and induces cell apoptosis.
SKLB-C05 exhibits markedly prioritized inhibitory activity on TOPK-positive CRC cells than TOPK-negative cells (HCT116 cell IC50=96 nM).
SKLB-C05 inhibits TOPK downstream signaling including ERK1/2, p38, and JNK1/2/3, as well as downregulation of FAK/Src- MMP signaling.
SKLB-C05 dramatically attenuates CRC tumor xenograft growth and completely suppressed hepatic metastasis of HCT116 cells (20 and 10 mg/kg/day).
| M.Wt | 394.899 | |
| Formula | C23H23ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gao T, et al. Cancer Lett. 2018 Dec 24. pii: S0304-3835(18)30737-7.
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