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Chemical Structure : SKLB325
CAS No.: 1612138-91-6
Catalog No.: PC-72265Not For Human Use, Lab Use Only.
SKLB325 (SKLB 325) is a potential inhibitor for JMJD6 with Kd of 0.755 uM by SPR assays, biochemical IC50 of 0.78 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SKLB325 (SKLB 325) is a potential inhibitor for JMJD6 with Kd of 0.755 uM by SPR assays, biochemical IC50 of 0.78 uM.
SKLB325 suppresses proliferation, induces apoptosis in ovarian cancer cells, inhibits angiogenesis in HUVECs, and inhibits migration in ovarian cancer cells and HUVECs in vitro.
SKLB325 upregulates the expression of p53 and its downstream effectors at both the mRNA and protein levels in vitro.
SKLB325 exhibits strong therapeutic effects on intraperitoneal dissemination xenograft mouse models, upregulates the expression of p53 as well as its downstream effectors at the protein level in vivo.
| M.Wt | 244.254 | |
| Formula | C12H12N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(2-(2-hydroxybenzylidene) hydrazinyl)-6-methylpyrimidin-4-ol |
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1. Zheng H, et al. Signal Transduct Target Ther. 2019 Jul 26;4:24.
2. Zhang C, et al. Clin Transl Med. 2021 Feb;11(2):e328.
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