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SKLB325

Chemical Structure : SKLB325

CAS No.: 1612138-91-6

SKLB325 (SKLB 325, SKLB-325)

Catalog No.: PC-72265Not For Human Use, Lab Use Only.

SKLB325 (SKLB 325) is a potential inhibitor for JMJD6 with Kd of 0.755 uM by SPR assays, biochemical IC50 of 0.78 uM.

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Biological Activity

SKLB325 (SKLB 325) is a potential inhibitor for JMJD6 with Kd of 0.755 uM by SPR assays, biochemical IC50 of 0.78 uM.
SKLB325 suppresses proliferation, induces apoptosis in ovarian cancer cells, inhibits angiogenesis in HUVECs, and inhibits migration in ovarian cancer cells and HUVECs in vitro.
SKLB325 upregulates the expression of p53 and its downstream effectors at both the mRNA and protein levels in vitro.
SKLB325 exhibits strong therapeutic effects on intraperitoneal dissemination xenograft mouse models, upregulates the expression of p53 as well as its downstream effectors at the protein level in vivo.

Physicochemical Properties

M.Wt 244.254
Formula C12H12N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2-(2-hydroxybenzylidene) hydrazinyl)-6-methylpyrimidin-4-ol

References

1. Zheng H, et al. Signal Transduct Target Ther. 2019 Jul 26;4:24.

2. Zhang C, et al. Clin Transl Med. 2021 Feb;11(2):e328.

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