SL44 | ClpP agonist | Probechem Biochemicals

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Chemical Structure : SL44

SL44 (HsClpP activator SL44)

Catalog No.: PC-23499Not For Human Use, Lab Use Only.

SL44 is a potent, small molecule activator /agonist of human caseinolytic protease P (HsClpP) with EC50 of 1.3 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SL44 is a potent, small molecule activator /agonist of human caseinolytic protease P (HsClpP) with EC50 of 1.3 uM.
SL44 inhibits the proliferation of HCCLM3 cells (IC50 = 3.1 μM, 21.4-fold higher than hit ADX-47273).
SL44 induces degradation of respiratory chain complex subunits and leads to apoptosis in HCC cells.
SL44 has potent tumor growth inhibitory activity and has a superior safety profile compared to the kinase inhibitor sorafenib.

Physicochemical Properties

M.Wt	410.88
Formula	C22H20ClFN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-(3-(3-chloro-4-fluorobenzyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methyl)benzonitrile

References

1. Liu S, et al. J Med Chem. 2024 Jul 11;67(13):10622-10642.

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SL44 (HsClpP activator SL44)

Biological Activity

Physicochemical Properties

References

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