SLB1122168 is a potent, specific inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits Spns2-mediated S1P release with IC50 of 94 nM.
SLB1122168 displays no activity agianst Mfsd2b, does not inhibit S1P release from mouse red blood cell at 10 uM.
SLB1122168 (10 and 30 mg/kg, i.p.) significantly and dose-dependently decreased the circulating lymphocytes, a pharmacodynamic indication of Spns2 inhibition, in mice and rats.
