Catalog No.: PC-61497Not For Human Use, Lab Use Only.
SLMP53-1 is a small molecule reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells.
SLMP53-1 is a small molecule reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells.
SLMP53-1 enhances p53 transcriptional activity and restores wt-like DNA binding ability to mut p53R280K.
SLMP53-1 inhibits the growth of wt/mut p53-expressing tumors in xenograft mice models, without apparent toxicity.
