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SM13

Chemical Structure : SM13

CAS No.: 1445992-93-7

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SM13 (p53-MDM2 inhibitor SM13)

Catalog No.: PC-62499Not For Human Use, Lab Use Only.

SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
    SM13 reduces cell proliferation and induces apoptosis in vitro in cells carrying either p53 WT or mutated gene, suggesting that its effect is independent from p53 transcriptional activity.
    SM13 induces cancer cell death in a dose-dependent manner through the activation of the mitochondrial-dependent death signalling in p53-mutated cells.
    SM13 reduces tumour growth in vivo.

    Physicochemical Properties

    M.Wt 481.405
    Formula C21H25BrN2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-bromo-3'-(cyclohexane carbonyl)-1-methyl-2-oxospiro[indoline-3,2'-thiazolidine

    References

    1. Sorriento D, et al. Br J Cancer. 2015 Jan 6;112(1):77-85.

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