Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SM360320
CAS No.: 226907-52-4
Catalog No.: PC-72050Not For Human Use, Lab Use Only.
SM360320 (CL-087, 1V136) is a potent, orally active and selective TLR7 agonist (ligand).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $388 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SM360320 (CL-087, 1V136) is a potent, orally active and selective TLR7 agonist (ligand).
SM360320 inhibited HCV replication in Huh-7 cells in a dose-dependent manner in the Huh-7 replicon system, reduced HCV mRNA and protein levels in isolated Huh-7 hepatocytes.
SM360320 induced in vivo secretion of interferon alpha (IFNalpha) and exerted a significant antitumor effect in CEA.Tg mice challenged with a syngenic tumor cell line expressing CEA.
SM360320 exerts significant antitumor effects and can act in association with DNA-EP for CEA-positive colon cancer and HER2-positive mammary carcinoma.
Repeated low dose administration of SM360320 induced hyporesponsiveness or tolerance to TLR2, -7, and -9 activators and limited the course of neural inflammation in an experimental allergic encephalomyelitis model.
| M.Wt | C15H17N5O3 | |
| Formula | 315.333 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
9-benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine |
|
1. Lee J, et al. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1828-33.
2. Keith B Gorden, et al. J Immunol. 2005 Feb 1;174(3):1259-68.
3. Hayashi T, et al. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2764-9.
4. Russo C, et al. Blood. 2011 May 26;117(21):5683-91.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
