SM360320 (CL-087, 1V136) is a potent, orally active and selective TLR7 agonist (ligand).
SM360320 inhibited HCV replication in Huh-7 cells in a dose-dependent manner in the Huh-7 replicon system, reduced HCV mRNA and protein levels in isolated Huh-7 hepatocytes.
SM360320 induced in vivo secretion of interferon alpha (IFNalpha) and exerted a significant antitumor effect in CEA.Tg mice challenged with a syngenic tumor cell line expressing CEA.
SM360320 exerts significant antitumor effects and can act in association with DNA-EP for CEA-positive colon cancer and HER2-positive mammary carcinoma.
Repeated low dose administration of SM360320 induced hyporesponsiveness or tolerance to TLR2, -7, and -9 activators and limited the course of neural inflammation in an experimental allergic encephalomyelitis model.
Physicochemical Properties
M.Wt
C15H17N5O3
Formula
315.333
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
9-benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine
References
1. Lee J, et al. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1828-33.
2. Keith B Gorden, et al. J Immunol. 2005 Feb 1;174(3):1259-68.
3. Hayashi T, et al. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2764-9.
4. Russo C, et al. Blood. 2011 May 26;117(21):5683-91.
