Chemical Structure : SMC247-9 hydrochloride
CAS No.:
1087750-47-7
SMC247-9 hydrochloride
(SMC 247-9 hydrochloride)
Catalog No.: PC-28116Not For Human Use, Lab Use Only.
SMC247-9 hydrochloride is a highly potent inhibitor of single-stranded DNA cytosine-to-uracil deaminase APOBEC3B (A3B) inhibitor with IC50 of 50 pM and MST KD of 300 pM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SMC247-9 hydrochloride is a highly potent inhibitor of single-stranded DNA cytosine-to-uracil deaminase APOBEC3B (A3B) inhibitor with IC50 of 50 pM and MST KD of 300 pM.
SMC247-9 reduces cellular A3B abundance and promotes IL-15 expression in tumor cells.
SMC247-9 reduces cellular A3B abundance and promoted IL-15 expression in tumor cells, thereby relieving tumor cell-mediated suppression of CD8+ T cells in an IL-15-dependent manner.
SMC247-9 suppresses tumor growth in the immune checkpoint blockade (ICB)-responsive MC38 model and synergized with anti-PD-L1 in the ICB-resistant TC-1 model.
SMC247-9 also attenuates macrophage chemotaxis and ameliorates anti-PD-1-exacerbated DSS-induced colitis-like intestinal inflammation.
Physicochemical Properties
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M.Wt
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245.70
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Formula
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C11H16ClNO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-2-amino-3-(4-hydroxy-3,5-dimethylphenyl)propanoic acid hydrochloride
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References
1. Ning H, et al. J Med Chem. 2026 Sep 10;69(17):20678-20697.
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