SMEI inhibitor 20e

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Chemical Structure : SMEI inhibitor 20e

Catalog No.: PC-26454Not For Human Use, Lab Use Only.

SMEI inhibitor 20e is a small molecule inhibitor targeting SCN1A-associated severe myoclonic epilepsy of infancy (SMEI), shows potent antiseizure efficacy in zebrafish behavioral assays and significantly reduces locomotion-related seizure parameters, elevates 5-HT levels via TPH2 upregulation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	373.69
Formula	C15H8ClF4N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-Chloro-4-fluorobenzyl)-5-(2-(trifluoromethyl)pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one

References

1. Kim DG, et al. J Med Chem. 2026 Feb 12;69(3):3362-3377.

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