Catalog No.: PC-72545Not For Human Use, Lab Use Only.
SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I).
SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I).
SMIP004-7 suppressed colony formation against various prostate (LNCaP, 22RV1,LAPC4), colon cancer (HCT116), and mouse triple-negative breast cancer (4T1) cell lines.
SMIP004-7 inhibits NADH oxidation activity and tumor hypoxia in vivo, promotes cancer immune surveillance.
SMIP004-7 stabilizes NDUFS2 in cells, NDUFS2 appears to play a unique role in the mechanism of SMIP004-7.
Physicochemical Properties
M.Wt
163.264
Formula
C11H17N
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-butyl-2-methylaniline
References
1. Shashi Jain, et al. Cell Chem Biol. 2021 Nov 23;S2451-9456(21)00479-7.
