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Chemical Structure : SMIP004-7
CAS No.: 72072-16-3
Catalog No.: PC-72545Not For Human Use, Lab Use Only.
SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 100 mg | $388 | In stock | |
| 250 mg | $558 | In stock | |
| 1 g | Get quote |
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SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I).
SMIP004-7 suppressed colony formation against various prostate (LNCaP, 22RV1,LAPC4), colon cancer (HCT116), and mouse triple-negative breast cancer (4T1) cell lines.
SMIP004-7 inhibits NADH oxidation activity and tumor hypoxia in vivo, promotes cancer immune surveillance.
SMIP004-7 stabilizes NDUFS2 in cells, NDUFS2 appears to play a unique role in the mechanism of SMIP004-7.
| M.Wt | 163.264 | |
| Formula | C11H17N | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-butyl-2-methylaniline |
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1. Shashi Jain, et al. Cell Chem Biol. 2021 Nov 23;S2451-9456(21)00479-7.
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