Chemical Structure : SMM-189
CAS No.:
1054451-07-8
SMM-189
(SMM189)
Catalog No.: PC-22115Not For Human Use, Lab Use Only.
SMM-189 is a selective cannabinoid receptor 2 (CB2) inverse agonist with Ki of 121.3 nM, 40-fold selective over CB1 receptor.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SMM-189 is a selective cannabinoid receptor 2 (CB2) inverse agonist with Ki of 121.3 nM, 40-fold selective over CB1 receptor.
SMM-189 prevents the rat primary microglia-mediated inflammation and shows moderate neuroprotection against N-methyl-D-aspartic acid (NMDA) receptor-mediated excitotoxicity in rat primary hippocampal cultures containing both neurons and glia.
SMM-189 (6 mg/kg, i.p., b.i.d.) prevented the seizure-induced cytokine surge in the brain, neuronal death, and behavioral impairments 24 h after status epilepticus (SE).
SMM-189 shows potential for the treatment of neurodegenerative disorders and traumatic brain injury.
Physicochemical Properties
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M.Wt
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359.20
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Formula
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C19H12Cl2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3',5'-dichloro-2,6-dihydroxy-[1,1'-biphenyl]-4-yl)(phenyl)methanone
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References
1. Alghamdi SS, et al. Bioorg Med Chem. 2021 Mar 1;33:116035.
2. Yu Y, et al. Mol Neurobiol. 2020 Jun;57(6):2830-2845.
3. Presley C, et al. Pharmacol Res Perspect. 2015 Aug;3(4):e00159.
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