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SMM-295

Chemical Structure : SMM-295

CAS No.: 1054451-22-7

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SMM-295 (SMM295;SMM 295)

Catalog No.: PC-60810Not For Human Use, Lab Use Only.

SMM-295 is a potent, selective cannabinoid receptor 2 (CB2) agonist with Ki of 12 nM, >30-fold selectivity over CB1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SMM-295 is a potent, selective cannabinoid receptor 2 (CB2) agonist with Ki of 12 nM, >30-fold selectivity over CB1.
    SMM-295 reduces cAMP production with a 66-fold selectivity for the CB2 versus the cannabinoid receptor 1 (CB1) in HEK-293 cells.
    SMM-295 reduces tubular damage and plasma markers of renal dysfunction (i.e., creatinine and NGAL) in acute kidney injury mice.

    Physicochemical Properties

    M.Wt 324.438
    Formula C20H20O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3'-methyl-4-(2-(thiophen-2-yl)propan-2-yl)-[1,1'-biphenyl]-2,6-diol

    References

    1. Pressly JD, et al. J Pharmacol Exp Ther. 2017 Nov 29. pii: jpet.117.245522.

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