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Chemical Structure : SMND-309
CAS No.: 1065559-56-9
Catalog No.: PC-43358Not For Human Use, Lab Use Only.
SMND-309 is a derivate of salvianolic acid B, attenuates apoptosis and ameliorates mitochondrial energy metabolism in rat cortical neurons.
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|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SMND-309 is a derivate of salvianolic acid B, attenuates apoptosis and ameliorates mitochondrial energy metabolism in rat cortical neurons.
SMND-309 increases cell survival rate, mitochondrial antioxidant enzyme activities, mitochondrial respiratory enzymes activities, mitochondrial respiratory control ratio and the adenosine triphosphate content, decreases mitochondrial malondialdehyde content, lactate dehydrogenase release, intracellular Ca(2+) level and caspase-3 activity in a concentration-dependent manner.
SMND-309 exhibits significantly higher potency as compared to salvianolic acid B, shows protective potential against cerebral ischaemic injury.
| M.Wt | 358.299 | |
| Formula | C18H14O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 3.7 mg/mL |
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| Chemical Name/SMILES |
Benzeneacetic acid, 6-[(1E)-2-carboxyethenyl]-α-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydroxy-, (αE)- |
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1. Tian J, et al. Basic Clin Pharmacol Toxicol. 2009 Feb;104(2):176-84.
2. Tian J, et al. Brain Res. 2009 Mar 31;1263:114-21.
3. Tian J, Phytomedicine. 2009 Aug;16(8):726-33.et al.
4. Hou J, et al. Eur J Pharmacol. 2011 Jan 10;650(1):390-5.
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