SMS121 | CD36 inhibitor | Probechem Biochemicals

Chemical Structure : SMS121

CAS No.: 949875-48-3

SMS121 (SMS-121)

Catalog No.: PC-22176Not For Human Use, Lab Use Only.

SMS121 (SMS-121) is a drug-like small molecule inhibitor of the very long/long chain fatty acid transporter CD36 (FAT, scavenger receptor class B member 3/SCARB3) with binding Kd of 5.57 uM.

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Biological Activity

SMS121 (SMS-121) is a drug-like small molecule inhibitor of the very long/long chain fatty acid transporter CD36 (FAT, scavenger receptor class B member 3/SCARB3) with binding Kd of 5.57 uM.
SMS121 affects the viability of KG-1 cells with IC50 of 156 uM, impairs lipid uptake and reduce the viability in AML cells.

Physicochemical Properties

M.Wt	355.39
Formula	C20H21NO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(4-(3-(4-(dimethylamino)phenyl)-3-oxoprop-1-en-1-yl)-2-methoxyphenoxy) acetic acid

References

1. Åbacka H, et al. Sci Rep. 2024 Apr 20;14(1):9104.

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SMS121 (SMS-121)

Biological Activity

Physicochemical Properties

References

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