SMU127 |CAS:903864-87-9 Probechem Biochemicals

Chemical Structure : SMU127

SMU127 (SMU-127;ZINC666243)

Catalog No.: PC-35705Not For Human Use, Lab Use Only.

SMU127 (SMU-127, ZINC666243) is a specific TLR1-TLR2 small molecule agonist with EC50 of 0.55 uM.

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Biological Activity

SMU127 (SMU-127, ZINC666243) is a specific TLR1-TLR2 small molecule agonist with EC50 of 0.55 uM.
SMU127 stimulates NF-κB activation and promotes TNFα secretion in human macrophages and mononuclear cells, inhibits the growth of breast cancer tumors in BABL/c mice.

Physicochemical Properties

M.Wt	337.438
Formula	C16H23N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-(4-methylpiperazine-1-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

References

1. Chen Z, et al. Chem Commun (Camb). 2018 Oct 9;54(81):11411-11414.

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SMU127 (SMU-127;ZINC666243)

Biological Activity

Physicochemical Properties

References

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