You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-SNS-032
SNS-032

Chemical Structure : SNS-032

CAS No.: 345627-80-7

SNS-032 (BMS-387032)

Catalog No.: PC-42052Not For Human Use, Lab Use Only.

SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.

Packing Price Stock Quantity
5 mg (Free Sample) $28 In stock
25 mg $88 In stock
50 mg $138 In stock
100 mg $228 In stock
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.
SNS-032 (BMS-387032) displays 10- and 20-fold selective over CDK1/cycB and CDK4/cycD (IC50=480 and 925 nM) respectively, and a panel of unrelated kinases, respectively.
SNS-032 (BMS-387032) blocks the cell cycle via inhibition of CDKs 2 and 7, and transcription via inhibition of CDKs 7 and 9, has an A2780 cellular cytotoxicity assay IC50 of 95 nM.
SNS-032 (BMS-387032) exhibits a efficacy profile in A2780 human ovarian carcinoma xenograft model.

Physicochemical Properties

M.Wt 380.528
Formula C17H24N4O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Piperidinecarboxamide, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-

References

1. Misra RN, et al. J Med Chem. 2004 Mar 25;47(7):1719-28.

2. Mukhopadhyay P, et al. Cancer Res. 2006 Feb 1;66(3):1758-66.

3. Chen R, et al. Blood. 2009 May 7;113(19):4637-45.

4. Heath EI, et al. Invest New Drugs. 2008 Feb;26(1):59-65.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: