SNS-032 |CAS:345627-80-7 Probechem Biochemicals

Chemical Structure : SNS-032

CAS No.: 345627-80-7

SNS-032 (BMS-387032)

Catalog No.: PC-42052Not For Human Use, Lab Use Only.

SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.

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5 mg (Free Sample)	$28	In stock
25 mg	$88	In stock
50 mg	$138	In stock
100 mg	$228	In stock
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Biological Activity

SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.
SNS-032 (BMS-387032) displays 10- and 20-fold selective over CDK1/cycB and CDK4/cycD (IC50=480 and 925 nM) respectively, and a panel of unrelated kinases, respectively.
SNS-032 (BMS-387032) blocks the cell cycle via inhibition of CDKs 2 and 7, and transcription via inhibition of CDKs 7 and 9, has an A2780 cellular cytotoxicity assay IC50 of 95 nM.
SNS-032 (BMS-387032) exhibits a efficacy profile in A2780 human ovarian carcinoma xenograft model.

Physicochemical Properties

M.Wt	380.528
Formula	C17H24N4O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Piperidinecarboxamide, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-

References

1. Misra RN, et al. J Med Chem. 2004 Mar 25;47(7):1719-28.

2. Mukhopadhyay P, et al. Cancer Res. 2006 Feb 1;66(3):1758-66.

3. Chen R, et al. Blood. 2009 May 7;113(19):4637-45.

4. Heath EI, et al. Invest New Drugs. 2008 Feb;26(1):59-65.

SNS-032 (BMS-387032)

Biological Activity

Physicochemical Properties

References

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