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You are here:Home-Chemical Inhibitors & Agonists-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-SNX-5422
SNX-5422

Chemical Structure : SNX-5422

CAS No.: 908115-27-5

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SNX-5422 (PF-04929113)

Catalog No.: PC-24852Not For Human Use, Lab Use Only.

SNX-5422 (PF-04929113) is the prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor, inhibits several signaling pathways and induces apoptosis in CRPC LNCaP tumors in vivo.

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10 mg $78 In stock
25 mg $128 In stock
50 mg $198 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SNX-5422 (PF-04929113) is the prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor, inhibits several signaling pathways and induces apoptosis in CRPC LNCaP tumors in vivo.

Physicochemical Properties

M.Wt 521.54
Formula C25H30F3N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

trans-4-((2-Carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl 2-aminoacetate

References

1. Lamoureux F, et al. Clin Cancer Res. 2011 Jul 15;17(14):4916.

2. Rajan A, et al. Clin Cancer Res. 2011 Nov 1;17(21):6831-9.

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