Chemical Structure : SNX631-6
CAS No.:
2456380-33-7
SNX631-6
Catalog No.: PC-24325Not For Human Use, Lab Use Only.
SNX631-6 is an equipotent analog of SNX631 and potent, selective inhibitor of CDK8 and CDK19 with Kd values of 0.25 and 0.3 nM respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SNX631-6 is an equipotent analog of SNX631 and potent, selective inhibitor of CDK8 and CDK19 with Kd values of 0.25 and 0.3 nM respectively.
SNX631-6 exhibits IC50 of 11.7 nM in cell-based NFκB-dependent reporter assay for CDK8/19 inhibition in wild type (WT) 293 cells, but not CDK8/19-double knockout (KO) 293 cells.
SNX631-6 inhibits cancer growth of MYC-CaP-CR tumors in isogenic FVB mice, with no detrimental effect on body weight.
SNX631-6 enhances the efficacy of platinum-based chemotherapy and paclitaxel in both platinum-sensitive and resistant OCCC cell lines.
SNX631-6 shows strong antitumor and anti-metastatic effects in vivo.
Physicochemical Properties
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M.Wt
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444.59
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Formula
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C22H20D6N6O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-amino-4-(4-(4-(bis(methyl-d3)carbamoyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide
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References
1. Li J, et al. J Clin Invest. 2024 Mar 28;134(10):e176709.
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