SOD1 stabilizer C7

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Chemical Structure : SOD1 stabilizer C7

Catalog No.: PC-26548Not For Human Use, Lab Use Only.

SOD1 stabilizer C7 is a SOD1-stabilizing small molecule preferentially bound the native-like conformation of SOD1, inhibits irreversible apo-SOD1 misfolding in vitro.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SOD1 stabilizer C7 is a SOD1-stabilizing small molecule preferentially bound the native-like conformation of SOD1, inhibits irreversible apo-SOD1 misfolding in vitro.
C7 binding selectively affected the accessibility of the pathogenic β6/β7 loop neo-epitope.
C7 binds holo-SOD1WT with MST IC50 of 6.32 uM.
Intranasal C7 treatment delays disease onset and prolongs survival in SOD1G93A ALS mice (males).
C7 attenuates astrocytic and microglial reactivity in the spinal cord of SOD1G93A mice.

Physicochemical Properties

M.Wt	412.48
Formula	C19H16N4O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-(3-methylimidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-4-sulfamoylbenzamide

References

1. Ranjithkumar Dhandapani, et al. Neurotherapeutics. 2026 Apr 10;23(3):e00904.

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